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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIK1 All Species: 18.18
Human Site: S512 Identified Species: 33.33
UniProt: P57059 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57059 NP_775490.2 783 84902 S512 S D S C L T F S A S K S P A G
Chimpanzee Pan troglodytes XP_531484 783 84972 S512 S D S C L T F S A S K S P A G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_544912 898 97147 A637 D S C L T F S A G D G P G A L
Cat Felis silvestris
Mouse Mus musculus Q60670 779 85009 S514 S D S C L P F S A S E G P A G
Rat Rattus norvegicus Q9R1U5 776 84890 S514 S D S C L P F S A S E G P A G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511894 801 88312 S519 S D S C L P S S S T E G S G A
Chicken Gallus gallus Q9IA88 798 88848 S512 S D S C L T S S S N D S S V A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 I564 L V T S P H P I P A V A P V D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_569972 1398 149888 G896 A S S S S S S G V L A G S A G
Honey Bee Apis mellifera XP_397175 718 80391 P496 P S C T P P P P M S P S P I T
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 K722 T S S T M M S K L I N K T P A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 K293 D T V E Q A K K I N E E I V Q
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 P414 D T F L S Q S P P T F Q Q Q S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 69.2 N.A. 81.3 81.6 N.A. 70.4 66.6 N.A. 32 N.A. 28.8 36.5 24.5 N.A.
Protein Similarity: 100 99.6 N.A. 73.6 N.A. 86.2 86.3 N.A. 77 76.6 N.A. 44 N.A. 38 50.9 39.4 N.A.
P-Site Identity: 100 100 N.A. 6.6 N.A. 80 80 N.A. 40 53.3 N.A. 6.6 N.A. 20 20 6.6 N.A.
P-Site Similarity: 100 100 N.A. 13.3 N.A. 86.6 86.6 N.A. 60 66.6 N.A. 26.6 N.A. 33.3 20 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28.2 27.2 N.A.
Protein Similarity: N.A. N.A. N.A. 41 42.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 8 0 8 31 8 8 8 0 47 24 % A
% Cys: 0 0 16 47 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 24 47 0 0 0 0 0 0 0 8 8 0 0 0 8 % D
% Glu: 0 0 0 8 0 0 0 0 0 0 31 8 0 0 0 % E
% Phe: 0 0 8 0 0 8 31 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 8 0 8 31 8 8 39 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 8 8 8 0 0 8 8 0 % I
% Lys: 0 0 0 0 0 0 8 16 0 0 16 8 0 0 0 % K
% Leu: 8 0 0 16 47 0 0 0 8 8 0 0 0 0 8 % L
% Met: 0 0 0 0 8 8 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 16 8 0 0 0 0 % N
% Pro: 8 0 0 0 16 31 16 16 16 0 8 8 47 8 0 % P
% Gln: 0 0 0 0 8 8 0 0 0 0 0 8 8 8 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 47 31 62 16 16 8 47 47 16 39 0 31 24 0 8 % S
% Thr: 8 16 8 16 8 24 0 0 0 16 0 0 8 0 8 % T
% Val: 0 8 8 0 0 0 0 0 8 0 8 0 0 24 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _